Send to:

Choose Destination
See comment in PubMed Commons below
ACS Macro Lett. 2012 Jun 19;1(6):706-708. Epub 2012 May 22.

Measuring the modulus and reverse percolation transition of a degrading hydrogel.

Author information

  • 1Department of Chemical and Biomolecular Engineering, University of Delaware, Allan P. Colburn Laboratory, 150 Academy Street, Newark, Delaware 19716 USA.


In light of the growing importance in understanding and controlling the physical cues presented to cells by artificial scaffolds, direct, temporally resolved measurements of the gel modulus are needed. We demonstrate that an interpolation of macro- and microrheology measurements provides a complete history of a hydrogel modulus during degradation through the reverse percolation transition. The latter is identified by microrheology, which captures the critical scaling behavior of reverse percolation, a transition of key importance in controlling cell migration, implant degradation, and tissue regeneration.

Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk