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Chem Commun (Camb). 2013 Mar 25;49(24):2436-8. doi: 10.1039/c3cc00243h.

Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.

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  • 1Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, USA.


We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46‚ÄČ656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

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