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Exp Ther Med. 2013 Mar;5(3):897-901. Epub 2013 Jan 4.

An uncommon malignant cutaneous squamomelanocytic tumor.

Author information

  • 1Department of Pathology, First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Abstract

The intermingling of two malignant neoplasms within the same cutaneous tumor is rare. No consensus has been reached for a clear definition and categorization. In the current study, we describe a cutaneous neoplasm; a squamomelanocytic tumor (SMT) with histological features combining those of a squamous cell carcinoma (SCC) and a malignant melanoma (MM). This is the second report of an oculocutaneous SMT, and concerns a subject with a 20-year history of solar lentigo coexisting with solar keratosis in the primary lesion. This type of tumor is quite rare, with a distinct cytological architecture and immunohistochemical features, and the differential diagnosis of SMT may be considered. However, the histogenesis, biological behavior and malignant potential of SMTs remain a matter of speculation. With regard to the treatment, complete surgical resection and close follow-up are recommended.

KEYWORDS:

histogenesis; solar keratosis; solar lentigo; squamomelanocytic tumor

PMID:
23407590
[PubMed]
PMCID:
PMC3570222
Free PMC Article
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