Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroimmunomodulation. 2013;20(3):127-33. doi: 10.1159/000346199. Epub 2013 Feb 12.

Acute painful stress and inflammatory mediator production.

Author information

  • 1UCLA Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. cgriffis55@gmail.com

Abstract

BACKGROUND:

Proinflammatory pathways may be activated under conditions of painful stress, which is hypothesized to worsen the experience of pain and place medically vulnerable populations at risk for increased morbidity.

OBJECTIVES:

To evaluate the effects of pain and subjective pain-related stress on proinflammatory activity.

METHODS:

A total of 19 healthy control subjects underwent a single standard cold-pressor pain test (CPT) and a no-pain control condition. Indicators of pain and stress were measured and related to inflammatory immune responses [CD8+ cells expressing the integrin molecule CD11a (CD811a), interleukin (IL)-1 receptor agonist (IL-1RA), and IL-6] immediately following the painful stimulus and compared to responses under no-pain conditions. Heart rate and mean arterial pressure were measured as indicators of sympathetic stimulation.

RESULTS:

CPT was clearly painful and generated an activation of the sympathetic nervous system. CD811a increased in both conditions, but with no statistically significantly greater increase following CPT (p<0.06). IL-1RA demonstrated a non-statistically significant increase following CPT (p<0.07). The change in IL-6 following CPT differed significantly from the response seen in the control condition (p<0.02).

CONCLUSIONS:

These findings suggest that CP acute pain may affect proinflammatory pathways, possibly through mechanisms related to adrenergic activation.

Copyright © 2013 S. Karger AG, Basel.

PMID:
23407214
[PubMed - indexed for MEDLINE]
PMCID:
PMC3932154
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Write to the Help Desk