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J Am Chem Soc. 2013 Mar 6;135(9):3387-90. doi: 10.1021/ja400648w. Epub 2013 Feb 25.

Palladium(0)-catalyzed alkynylation of C(sp3)-H bonds.

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  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.


The alkynylation of β-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L(n)] complexes to activate C(sp(3))-H bonds.

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