Format

Send to

Choose Destination
See comment in PubMed Commons below
Tunis Med. 2013 Jan;91(1):6-11.

[Aromatases inhibitors for breast cancer in menopausal patients].

[Article in French]

Author information

  • 1Service de carcinologie médicale, Hôpital Abderrahman Mami, Ariana, Tunis, Tunisie.

Abstract

AIMS:

To analyze the litterature data concerning the results of the main international randomized trials of adjuvant Aromarase Inhibitors (AI) in adjuvant setting for early breast cancer and the impact on daily practice in the management of breast cancer.

METHODS:

We selected through a litterature review 30 publications concerned the topic of AI RESULTS: They concerned the large ATAC, BIG, MA17 and IES concerning anastrozole, letrozole and exemestane . AI have been compared to tamoxifen in upfront of swich intents and showed a superiority to reduce, mortality rate, controlateral breast cancer risk, a better tolerance profile compared to tamoxifen and a sigificant benefit in term of disease-free survival. These results made a revolution in the adjuvant BC treatment, leading to the systematic use of upfront AI in menopaused patients.

CONCLUSION:

Adjuvant hormonotherapy in menopaused patients is now based on AI and proved its superiority to tamoxifen in term of distant, controlateral risks reduction and disease-free survival, less for overall survival.

PMID:
23404601
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Tunisian Society for Medical Sciences
    Loading ...
    Write to the Help Desk