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  • PMID: 23404524 was deleted because it is a duplicate of PMID: 24261769
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Mod Rheumatol. 2014 Jan;24(1):129-36. doi: 10.3109/14397595.2013.852854.

Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis.

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  • 1Institute of Medical Science, St. Marianna University School of Medicine , 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8512 , Japan.

Abstract

OBJECTIVES:

We aimed to identify a serum biomarker for evaluating the disease activity of relapsing polychondritis (RP).

METHODS:

We measured and compared serum levels of 28 biomarkers potentially associated with this disease, including soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), high-sensitivity C-reactive protein (hs-CRP), and cartilage oligomeric matrix protein (COMP), in 15 RP patients and 16 healthy donors (HDs). We divided the 15 RP patients into active RP (n = 8) and inactive RP (n = 7) groups, depending on the extent of the disease, and compared candidate markers between groups. The localization of membrane-bound TREM-1 in the affected tissue was examined by immunohistochemistry.

RESULTS:

Serum levels of sTREM-1, interferon-γ, chemokine (C-C motif) ligand 4, vascular endothelial growth factor, and matrix metalloproteinases-3 were significantly higher in RP patients than HDs. Among these markers, sTREM-1 had the highest sensitivity and specificity (86.7 and 86.7 %, respectively). Furthermore, the serum level of sTREM-1 was significantly higher in active RP patients than inactive RP patients (p = 0.0403), but this was not true for hs-CRP or COMP. TREM-1 was expressed on endothelial cells in RP lesions.

CONCLUSIONS:

The serum level of sTREM-1 may be a useful marker of disease activity in RP.

PMID:
24261769
[PubMed - indexed for MEDLINE]
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