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FEBS Lett. 2013 Apr 17;587(8):1247-57. doi: 10.1016/j.febslet.2013.01.047. Epub 2013 Feb 10.

Deciphering post-translational modification codes.

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  • 1Department of Biology, Tufts University, 200 Boston Ave. Suite 4700, Medford, MA 02155, USA.

Abstract

Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within proteins are modified on multiple amino acid sidechains by diverse enzymes to create a myriad of possible protein species. How these combinations of PTMs lead to distinct biological outcomes is only beginning to be understood. This manuscript highlights several examples of combinatorial PTMs in proteins, and describes recent technological developments, which are driving our ability to understand how PTM patterns may "code" for biological outcomes.

Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PMID:
23402885
[PubMed - indexed for MEDLINE]
PMCID:
PMC3888991
Free PMC Article
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