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[The role of feeding behaviour hormones in the development of cholelithiasis].

[Article in Russian]

Abstract

THE PURPOSE. To analyze the possible association between gallstone disease (GSD), and some adipokine: leptin, adiponectin, ghrelin, resistin, kaheksin (TNFalpha), visfatin. RECENT EVIDENCE IN THE LITERATURE. The prevalence of GSD increases by a factor not so much with age (in women - 6.0%, 7.9%, 8.5% and 18.6%, respectively, four age decade from 25 to 64 years - according to the epidemiological study in the frame of the WHO "Monica" in Novosibirsk in 1994-1995 years), but with metabolic disorders: GSD diagnosed in 17.6% in diabetes mellitus, in obesity III-IV degree - up to 100%. Leptin regulates the expression of genes responsible for the pathogenesis of cholesterol GSD -cholecystokinin receptor gene A, acetylcholine receptor beta2, Ca-calmodulin-dependent protein kinase, mucin3, carboxylesterazy, HMG-CoA reductase. Was found negative correlation of GSD with adiponectin levels and positive - with visfatin levels. Elevated ghrelin levels performs protective role to GSD (OR = 0,27, p = 0,02). In the analysis of GSD-associated regions on chromosome 1 p, genes TNFR2 receptor and TNFRSF1B included in a number of positional candidate genes.

PMID:
23402153
[PubMed - indexed for MEDLINE]
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