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Clin Chem. 2013 Apr;59(4):617-28. doi: 10.1373/clinchem.2012.187617. Epub 2013 Feb 11.

The human gut microbiome and body metabolism: implications for obesity and diabetes.

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  • 1Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Abstract

BACKGROUND:

Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders.

CONTENT:

Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways.

CONCLUSION:

Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes.

© 2013 American Association for Clinical Chemistry

PMID:
23401286
[PubMed - indexed for MEDLINE]
PMCID:
PMC3974587
Free PMC Article
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