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J Biomed Opt. 2013 Feb;18(2):27009. doi: 10.1117/1.JBO.18.2.027009.

Recovering intrinsic fluorescence by Monte Carlo modeling.

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  • 1Philips Research, Minimally Invasive Healthcare Department, High Tech Campus 34, 5656 AE Eindhoven, The Netherlands.


We present a novel way to recover intrinsic fluorescence in turbid media based on Monte Carlo generated look-up tables and making use of a diffuse reflectance measurement taken at the same location. The method has been validated on various phantoms with known intrinsic fluorescence and is benchmarked against photon-migration methods. This new method combines more flexibility in the probe design with fast reconstruction and showed similar reconstruction accuracy as found in other reconstruction methods.

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