Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.
Interactions of tetramisole, imidazo[2,1-b]thiazolic derived or immunomodulatory agents with human serum albumin (HSA) and immunoglobulins G and A has been investigated in vitro using polyacrylamide gel electrophoresis and immunoelectrophoresis. The results suggest that only the chemical structure type of tetramisole is able to induce a protein-protein interaction described as a mechanism of disulfide-sulfhydryl interchange reactions. The groups of atoms involved in the interaction are characterized.