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1: Arzneimittelforschung. 1990 Jan;40(1):55-7.Links

Drug-protein interactions. Comparative studies of levamisole and structural analogs or agents with immunomodulatory effect on the mechanism of protein aggregation.

Chicault M, Luu-Duc C, Boucherle A.

Unité de Formation et de Recherche de Pharmacie, Université Joseph Fourier Grenoble, Meylan, France.

Interactions of tetramisole, imidazo[2,1-b]thiazolic derived or immunomodulatory agents with human serum albumin (HSA) and immunoglobulins G and A has been investigated in vitro using polyacrylamide gel electrophoresis and immunoelectrophoresis. The results suggest that only the chemical structure type of tetramisole is able to induce a protein-protein interaction described as a mechanism of disulfide-sulfhydryl interchange reactions. The groups of atoms involved in the interaction are characterized.

PMID: 2340000 [PubMed - indexed for MEDLINE]