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Carbohydr Polym. 2013 Feb 15;92(2):1752-60. doi: 10.1016/j.carbpol.2012.11.029. Epub 2012 Nov 19.

Fabrication, properties and bioapplications of cellulose/collagen hydrolysate composite films.

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  • 1Department of Chemistry, Wuhan University, Wuhan 430072, PR China.


In this work, a series of cellulose/collagen hydrolysate (RC/CH) films were prepared in NaOH/urea aqueous solution via a simple, low-cost and green pathway. To overcome the disadvantages (brittleness, poor water resistance) of CH as biomaterials, CH was combined with regenerated cellulose (RC) film to construct RC/CH composite materials, leading to vast improvement of the water resistance of CH. Crosslinking with genipin further improved the mechanical properties of the RC/CH films in the wet state. Their structure and properties were characterized by elemental analysis, Fourier transform infra-red (FT-IR) spectra, ultraviolet-visible (UV-vis), scanning electron microscopy (SEM), amino acid analysis, tensile testing, cell adhesion and toxicity tests. The mechanical properties and water resistance of the crosslinked RC/CH films were significantly improved, which made collagen hydrolysate as biomaterial could be used at wet state. Moreover, the RC/CH films exhibited good biocompatibility by proliferation of COS7 cells on the surface, supporting cell adhesion and growth.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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