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Bioorg Med Chem Lett. 2013 Mar 15;23(6):1786-8. doi: 10.1016/j.bmcl.2013.01.037. Epub 2013 Jan 23.

Ceramicines from Chisocheton ceramicus as lipid-droplets accumulation inhibitors.

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  • 1Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.

Abstract

In our search for lipid-droplets accumulation (LDA) inhibitors, some ceramicines, a series of limonoids isolated from the barks of Chisocheton ceramicus, were discovered to be active as anti-LDA. Preliminary structure-activity relationships (SAR) of ceramicines as LDA inhibitors based on ceramicines A-L (1-12) and ceramicine B derivatives were described.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23395661
[PubMed - indexed for MEDLINE]
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