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J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):184-8. doi: 10.1097/QAI.0b013e318289822d.

Nevirapine inhibits the anti-HIV activity of CD8+ cells.

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  • 1Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-1270, USA.


Antiretroviral therapy (ART) significantly reduced the CD8 cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8(+) cells from long-term survivors were cocultured with HIV-infected CD4(+) cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8(+) cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8(+) cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8(+) cells and thus could influence the effectiveness of antiretroviral therapy.

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