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Pain. 1990 Jan;40(1):29-34.

The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy.

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  • 1Department of Neurology, Gentofte Hospital, Copenhagen, Denmark.

Abstract

In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.

PMID:
2339012
[PubMed - indexed for MEDLINE]
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