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JAMA. 2013 Feb 6;309(5):485-6. doi: 10.1001/jama.2012.193412.

Opioid analgesics for rheumatoid arthritis pain.

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  • 1Rheumatology Unit, The Queen Elizabeth Hospital, 28 Woodville Rd, Woodville S, South Australia 5011, Australia.


CLINICAL QUESTION Do the benefits of opioid analgesics outweigh the risks in patients with persistent pain due to rheumatoid arthritis? BOTTOM LINE Weak opioids (such as codeine, dextropropoxyphene, and tramadol) may be effective in the short-term management of rheumatoid arthritis pain, but adverse effects are common and may outweigh the benefits; alternative analgesics should be considered first.

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