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Cell Res. 2013 May;23(5):592-4. doi: 10.1038/cr.2013.20. Epub 2013 Feb 5.

hESC-derived pancreatic progenitors.

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  • 1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

Successful derivation of pancreatic progenitors from human embryonic stem cells (hESCs) in vitro and further differentiation towards functional β cells in vivo may create the possibility of using hESC-derived pancreatic progenitors (PPs), instead of derived β cells, as an alternative transplantable source in β cell replacement therapy. Here we discuss present approaches, as well as future alternatives, in the fields of basic and clinic research on β cell differentiation, derivation and transplantation.

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