Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Daru. 2013 Feb 2;21(1):12. doi: 10.1186/2008-2231-21-12.

A New extractive spectrophotometric method for determination of rizatriptan dosage forms using bromocresol green.

Author information

  • 1Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran. souri@sina.tums.ac.ir.

Abstract

BACKGROUND AND THE PURPOSE OF THE STUDY:

Rizatriptan is used effectively for the treatment of migraine headache. In this study, a simple, rapid and low cost spectrophotometric method based on the ion-pair complexation is proposed for the determination of rizatriptan in raw material and dosage forms.

METHODS:

The ion-pair complexation using bromocresol green as reagent was performed in a buffer solution and the absorbance was measured by a spectrophotometer. The ion-pair formation conditions were optimized and the accuracy and precision of the method were calculated.

RESULTS AND MAJOR CONCLUSION:

Best results were achieved by using 6 ml of the bromocresol green reagent in the presence of phosphate buffer (pH 3.0). The stoichiometry of the resulted complex was 1:1. The within-day and between-day precision values were lower than 2.9 and 1.8 percent for the calibration range of 0.5-50 and 10-100 μg/ml, respectively. The proposed method was successfully used for the determination of rizatriptan in dosage forms without any interference.

PMID:
23374246
[PubMed]
PMCID:
PMC3608254
Free PMC Article

Images from this publication.See all images (6)Free text

Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk