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Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5510-3. doi: 10.1109/EMBC.2012.6347242.

An analysis of the expression locus of long-term potentiation in hippocampal CA1 neurons.

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  • 1Department of Neuroscience, University of Southern California, Los Angeles, CA 90089, USA. shaneroa@usc.edu

Abstract

Long-term potentiation (LTP) has long been understood as an increase in the potency of a synaptic connection between two neurons. In this study, we combine a previously developed two-stage cascade model with electrophysiological recordings of rat hippocampal CA1 pyramidal cells both before and after LTP to analyze linear and nonlinear contributions of pre and post-synaptic partners to the strengthening of their synaptic connectivity. The result suggests that the major nonlinear expression locus of LTP exists in the post-synaptic side. Additionally, the report reveals that LTP should be understood not only in the traditional view as a change in the magnitude of communication between two cells, but also as a change in their temporal coding properties of information exchange.

PMID:
23367177
[PubMed - indexed for MEDLINE]
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