Send to:

Choose Destination
See comment in PubMed Commons below
Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5510-3. doi: 10.1109/EMBC.2012.6347242.

An analysis of the expression locus of long-term potentiation in hippocampal CA1 neurons.

Author information

  • 1Department of Neuroscience, University of Southern California, Los Angeles, CA 90089, USA.


Long-term potentiation (LTP) has long been understood as an increase in the potency of a synaptic connection between two neurons. In this study, we combine a previously developed two-stage cascade model with electrophysiological recordings of rat hippocampal CA1 pyramidal cells both before and after LTP to analyze linear and nonlinear contributions of pre and post-synaptic partners to the strengthening of their synaptic connectivity. The result suggests that the major nonlinear expression locus of LTP exists in the post-synaptic side. Additionally, the report reveals that LTP should be understood not only in the traditional view as a change in the magnitude of communication between two cells, but also as a change in their temporal coding properties of information exchange.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IEEE Engineering in Medicine and Biology Society
    Loading ...
    Write to the Help Desk