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Infect Dis Obstet Gynecol. 2013;2013:813238. doi: 10.1155/2013/813238. Epub 2013 Jan 10.

CD8⁺CXCR5⁺ T cells regulate pathology in the genital tract.

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  • 1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.

Abstract

We have identified a CD8⁺CXCR5⁺ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic studies show that CD8⁺CXCR5⁺ cells express markers of T regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (perforin). Cxcr5⁻/⁻ mice have significantly lower numbers of CD8⁺ cells and lack the CD8⁺CXCR5⁺ population while the total number of CD4⁺ cells is equivalent between mouse strains. The transfer of CD8⁺ splenocytes from WT mice reduces the oviduct dilation seen in Cxcr5⁻/⁻ mice following C. muridarum infection. Future studies will investigate the mechanism by which this cell type regulates genital tract pathology.

PMID:
23365491
[PubMed - indexed for MEDLINE]
PMCID:
PMC3556439
Free PMC Article

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