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Chembiochem. 2013 Feb 11;14(3):295-300. doi: 10.1002/cbic.201200711. Epub 2013 Jan 31.

Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization.

Author information

  • 1Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Abstract

In the third place: Inspired by the tetrahydroisoquinoline (THIQ) alkaloid noscapine, inhibitors of tubulin polymerization that bind to a site different from the colchicine and the vinca alkaloid binding sites have been synthesized. One compound is more potent than noscapine in HeLa cells and can overcome resistance to chemotherapeutics.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
23364933
[PubMed - indexed for MEDLINE]
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