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Chem Soc Rev. 2013 May 21;42(10):4297-309. doi: 10.1039/c3cs35457a. Epub 2013 Jan 30.

Design of chemical glycosyl donors: does changing ring conformation influence selectivity/reactivity?

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  • 1National Institute of Informatics (NII), Hitotsubashi 2-1-2, Tokyo 101-8430, Japan.


This tutorial review focuses on the design of glycosyl donors, especially on attempts to control selectivity/reactivity by employing bulky substituents, cyclic protecting groups, or bridged structures. These structural modifications are performed to change the conformational distributions of pyranoside/furanoside rings. We also briefly discuss this issue with regard to studies on furanosides and enzymatic glycosylation reactions. Readers will find that some of the designed glycosyl donors have been used to achieve total syntheses of natural products.

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