Send to:

Choose Destination
See comment in PubMed Commons below
RNA Biol. 2013 Mar;10(3):367-70. doi: 10.4161/rna.23663. Epub 2013 Jan 30.

New roles for microRNAs in cross-species communication.

Author information

  • 1Jiangsu Engineering Research Center for microRNA Biology and Biotechnology; State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, P.R. China.


Communication between cells ensures coordinated behavior. In prokaryotes, this signaling is typically referred to as quorum sensing, whereas in eukaryotic cells, communication occurs through hormones. In recent years, reports have shown that small noncoding RNAs, called microRNAs (miRNAs), can be transmitted from one species to another, inducing signal interference in distant species, even in a cross-kingdom manner. This new mode of cross-species communication might mediate symbiotic and pathogenic relationships between various organisms (e.g., microorganisms and their hosts). Here, we discuss several recent studies concerning miRNA-mediated cross-species gene regulation.


LDLRAP1; MIR168a; cross-species communication; malaria parasite; miR-451; microRNA; virus

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Write to the Help Desk