Format

Send to

Choose Destination
See comment in PubMed Commons below
Epigenetics. 2013 Mar;8(3):237-45. doi: 10.4161/epi.23790. Epub 2013 Jan 30.

Epigenetic regulation of estrogen signaling in breast cancer.

Author information

  • 1Université de Franche-Comté, Laboratoire de Biochimie, EA3922, Expression Génique et Pathologies du Système Nerveux Central, SFRIBCT FED 4234, UFR Sciences et Techniques, Besançon, France. eric.hervouet@univ-fcomte.fr

Abstract

Estrogen signaling is mediated by ERα and ERβ in hormone dependent, breast cancer (BC). Over the last decade the implication of epigenetic pathways in BC tumorigenesis has emerged: cancer-related epigenetic modifications are implicated in both gene expression regulation, and chromosomal instability. In this review, the epigenetic-mediated estrogen signaling, controlling both ER level and ER-targeted gene expression in BC, are discussed: (1) ER silencing is frequently observed in BC and is often associated with epigenetic regulations while chemical epigenetic modulators restore ER expression and increase response to treatment;(2) ER-targeted gene expression is tightly regulated by co-recruitment of ER and both coactivators/corepressors including HATs, HDACs, HMTs, Dnmts and Polycomb proteins.

KEYWORDS:

DNA methylation; breast cancer; epigenetic; estrogen; histones

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Write to the Help Desk