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Fertil Steril. 2013 May;99(6):1779-85. doi: 10.1016/j.fertnstert.2012.12.042. Epub 2013 Jan 26.

Seasonal effects on vitamin D status influence outcomes of lifestyle intervention in overweight and obese women with polycystic ovary syndrome.

Author information

  • 1Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, South Australia, Australia. rebecca.thomson@unisa.edu.au

Abstract

OBJECTIVE:

To investigate the effect of undertaking lifestyle interventions during periods of seasonal change on vitamin D status and health outcomes in overweight/obese women with polycystic ovary syndrome (PCOS).

DESIGN:

Retrospective, unplanned secondary analysis of two cohorts during different seasons.

SETTING:

Outpatient clinical research unit.

PATIENT(S):

Fifty overweight/obese women with PCOS.

INTERVENTION(S):

Twenty-week lifestyle modification program (Clinical Trials registration no.: ACTRN12606000198527); one cohort started in winter and finished in summer, and one started in summer and finished in winter.

MAIN OUTCOME MEASURE(S):

25-Hydroxyvitamin D (25OH-D), weight, waist circumference (WC), body composition, cardiovascular disease (CVD) risk factors, and menstrual cycle length.

RESULT(S):

Baseline 25OH-D levels were 27.6 ± 9.0 nmol/L. The winter cohort had lower 25OH-D levels at baseline, which increased over 20 weeks, whereas the summer cohort started with higher levels which decreased. Changes in 25OH-D were inversely correlated with changes in WC and cholesterol when controlling for baseline values, such that increases in 25OH-D were associated with greater reductions in WC and cholesterol.

CONCLUSION(S):

Obesity and CVD risk profiles improved in vitamin D-deficient women with PCOS after a 20-week lifestyle intervention during which vitamin D status improved with seasonal change.

CLINICAL TRIAL REGISTRATION NUMBER:

ACTRN12606000198527.

Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
23357457
[PubMed - indexed for MEDLINE]
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