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Front Microbiol. 2013 Jan 25;4:5. doi: 10.3389/fmicb.2013.00005. eCollection 2013.

Preparing synthetic biology for the world.

Author information

  • 1Leukippos Institute Berlin, Germany.

Abstract

Synthetic Biology promises low-cost, exponentially scalable products and global health solutions in the form of self-replicating organisms, or "living devices." As these promises are realized, proof-of-concept systems will gradually migrate from tightly regulated laboratory or industrial environments into private spaces as, for instance, probiotic health products, food, and even do-it-yourself bioengineered systems. What additional steps, if any, should be taken before releasing engineered self-replicating organisms into a broader user space? In this review, we explain how studies of genetically modified organisms lay groundwork for the future landscape of biosafety. Early in the design process, biological engineers are anticipating potential hazards and developing innovative tools to mitigate risk. Here, we survey lessons learned, ongoing efforts to engineer intrinsic biocontainment, and how different stakeholders in synthetic biology can act to accomplish best practices for biosafety.

KEYWORDS:

biosafety research; containment of biohazards; risk assessment; synthetic biology

PMID:
23355834
[PubMed]
PMCID:
PMC3554958
Free PMC Article
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