Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Gynaecol Obstet. 2013 Mar;120(3):257-61. doi: 10.1016/j.ijgo.2012.09.022. Epub 2013 Jan 23.

Effect of 2 referral intervals on diagnostic discordance between cytology and histology at a colposcopy clinic.

Author information

  • 1Department of Obstetrics and Gynecology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa. fsaayman@hotmail.com

Abstract

OBJECTIVE:

To determine the effect of the time interval between cervical cytology screening and histology at treatment on grade of cervical disease.

METHODS:

In a retrospective cross-sectional study at a colposcopy clinic in Soweto, Johannesburg, South Africa, data were compared from women with cytologic abnormalities referred for colposcopy between April 2003 and June 2010 to determine whether early (≤ 180 days) or late (> 180 days) referral had an impact on dysplasia grade.

RESULTS:

In the early and late referral groups, there were 213 (13.43%) and 201 (14.63%) women, respectively, with upgrading of cervical dysplasia (P=0.35), and 1373 (86.57%) and 1173 (85.37%) women, respectively, with downgrading or no change (P=0.35). Risk factors for upgrading were HIV infection (odds ratio [OR], 1.63; P<0.001) and condom use (OR, 1.30; P=0.02). Four cases (0.68%) of invasion among women with low-grade squamous intraepithelial lesion (LSIL) and 50 cases (2.11%) among women with high-grade SIL (HSIL) were not detected by cytology. Risk factors for invasive disease on histology were age (OR, 1.09 per year; P<0.001), parity (OR, 1.32 per pregnancy; P<0.001), and HSIL on cytology (OR, 3.17; P=0.03).

CONCLUSION:

There was no difference in the up- or downgrading of cervical dysplasia between the 2 referral groups.

Copyright © 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

PMID:
23352734
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk