Send to:

Choose Destination
See comment in PubMed Commons below
Int J Gynaecol Obstet. 2013 Mar;120(3):257-61. doi: 10.1016/j.ijgo.2012.09.022. Epub 2013 Jan 23.

Effect of 2 referral intervals on diagnostic discordance between cytology and histology at a colposcopy clinic.

Author information

  • 1Department of Obstetrics and Gynecology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa.



To determine the effect of the time interval between cervical cytology screening and histology at treatment on grade of cervical disease.


In a retrospective cross-sectional study at a colposcopy clinic in Soweto, Johannesburg, South Africa, data were compared from women with cytologic abnormalities referred for colposcopy between April 2003 and June 2010 to determine whether early (≤ 180 days) or late (> 180 days) referral had an impact on dysplasia grade.


In the early and late referral groups, there were 213 (13.43%) and 201 (14.63%) women, respectively, with upgrading of cervical dysplasia (P=0.35), and 1373 (86.57%) and 1173 (85.37%) women, respectively, with downgrading or no change (P=0.35). Risk factors for upgrading were HIV infection (odds ratio [OR], 1.63; P<0.001) and condom use (OR, 1.30; P=0.02). Four cases (0.68%) of invasion among women with low-grade squamous intraepithelial lesion (LSIL) and 50 cases (2.11%) among women with high-grade SIL (HSIL) were not detected by cytology. Risk factors for invasive disease on histology were age (OR, 1.09 per year; P<0.001), parity (OR, 1.32 per pregnancy; P<0.001), and HSIL on cytology (OR, 3.17; P=0.03).


There was no difference in the up- or downgrading of cervical dysplasia between the 2 referral groups.

Copyright © 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk