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Chem Biol. 2013 Jan 24;20(1):5-7. doi: 10.1016/j.chembiol.2013.01.004.

Small molecule disruption of B. subtilis biofilms by targeting the amyloid matrix.

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  • 1Department of Chemistry, Umeå University, 90187 Umeå, Sweden.

Abstract

Small molecule inhibitors of amyloid aggregation have potential as treatment for a variety of conditions. In this issue of Chemistry & Biology, Romero and colleagues use amyloid-dependent B. subtilis biofilm formation to screen for amyloid inhibitors, identifying compounds that not only inhibit B. subtilis biofilm formation but also ones that disrupt preformed biofilms.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23352134
[PubMed]
PMCID:
PMC3646361
Free PMC Article
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