Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann Endocrinol (Paris). 2013 Feb;74(1):45-8. doi: 10.1016/j.ando.2012.11.009. Epub 2013 Jan 23.

Association of the G-250A promoter polymorphism in the hepatic lipase gene with the risk of type 2 diabetes mellitus.

Author information

  • 1Center for Reproductive Medicine, First Affiliated Hospital of ZhengZhou University, 1, Jianshe Road, Zhengzhou, 450000, PR China.

Abstract

OBJECTIVE:

Variants in hepatic lipase (HL) gene which is a lipolytic enzyme involved in the metabolism of plasma lipoprotein and regulating lipid and lipoprotein metabolism are potential candidate genes for type 2 diabetes. Association of the polymorphisms in the promoter region of the HL gene (LIPC) to the plasma HDL-C concentration has been investigated. In this study, we investigated whether the G-250A polymorphism of LIPC is associated with type 2 diabetes in Chinese Han population.

SUBJECTS AND METHODS:

A total of 130 patients with type 2 diabetes and 133 healthy subjects as control were randomly selected from January 2008 to January 2011 in endocrine wards of Zhengzhou People's Hospital. The G-250A polymorphisms were studied by polymerase chain reaction and restriction fragment length polymorphism. A logistic regression analysis was performed to determine the association between the rare allele and type 2 diabetes mellitus.

RESULTS:

The frequency of the -250A allele was 0.297 in the T2DM group and 0.388 in the control group (P<0.05), with the difference remaining significant.

CONCLUSIONS:

Patients who are carrying of the -250A allele in the promoter of the LIPC gene are susceptible to type 2 diabetes mellitus in Chinese Han population.

Copyright © 2012 Elsevier Masson SAS. All rights reserved.

PMID:
23351562
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Masson (France)
    Loading ...
    Write to the Help Desk