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Pathol Res Pract. 2013 Feb 15;209(2):132-4. doi: 10.1016/j.prp.2012.12.004. Epub 2013 Jan 21.

Gastric undifferentiated carcinoma with diffuse c-kit overexpression and focal neuroendocrine differentiation.

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  • 1Division of Pathology, Saga Prefectural Hospital, Koseikan, Saga, Japan. mori-d@koseikan.jp

Abstract

A case of gastric undifferentiated carcinoma with diffuse c-kit overexpression and focal neuroendocrine differentiation is described. A 76-year-old man presented appetite loss for 1 month. Gastric endoscopy showed an exophytic huge nodular mass with central ulceration at the gastric prepylorus. Distal gastrectomy was performed with lymph node dissection. Histology indicated anaplastic medium- to large-sized round tumor cells in discohesive sheets. Adenocarcinomatous areas forming tubular glands or with intracytoplasmic mucin on PAS and Alcian-blue staining were not found in any sections. Immunohistochemistry showed that the tumor cells were diffusely positive for cytokeratin, vimentin, c-kit and focally positive for chromogranin A and synaptophysin. We hypothesized that c-kit overexpression of this tumor was attributed to neuroendocrine differentiation.

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PMID:
23347914
[PubMed - indexed for MEDLINE]
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