Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Emerg Infect Dis. 2013 Feb;19(2):237-45. doi: 10.3201/eid1902.121220.

Phylogenetic and ecologic perspectives of a monkeypox outbreak, southern Sudan, 2005.

Author information

  • 1Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. inp7@cdc.gov

Abstract

Identification of human monkeypox cases during 2005 in southern Sudan (now South Sudan) raised several questions about the natural history of monkeypox virus (MPXV) in Africa. The outbreak area, characterized by seasonally dry riverine grasslands, is not identified as environmentally suitable for MPXV transmission. We examined possible origins of this outbreak by performing phylogenetic analysis of genome sequences of MPXV isolates from the outbreak in Sudan and from differing localities. We also compared the environmental suitability of study localities for monkeypox transmission. Phylogenetically, the viruses isolated from Sudan outbreak specimens belong to a clade identified in the Congo Basin. This finding, added to the political instability of the area during the time of the outbreak, supports the hypothesis of importation by infected animals or humans entering Sudan from the Congo Basin, and person-to-person transmission of virus, rather than transmission of indigenous virus from infected animals to humans.

PMID:
23347770
[PubMed - indexed for MEDLINE]
PMCID:
PMC3559062
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for CDC-NCEZID Icon for PubMed Central
    Loading ...
    Write to the Help Desk