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Curr Opin Genet Dev. 2013 Apr;23(2):140-6. doi: 10.1016/j.gde.2012.12.007. Epub 2013 Jan 21.

Chromatin dynamics at the replication fork: there's more to life than histones.

Author information

  • 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. whitehoi@mskcc.org

Abstract

Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins--including histones--must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.

Published by Elsevier Ltd.

PMID:
23347596
[PubMed - indexed for MEDLINE]
PMCID:
PMC3657310
Free PMC Article
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