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J Nat Prod. 2013 Feb 22;76(2):230-6. doi: 10.1021/np300699f. Epub 2013 Jan 24.

Anti-inflammatory diterpenoids from Croton tonkinensis.

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  • 1Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, Republic of China.


Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.

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