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J Nat Prod. 2013 Feb 22;76(2):230-6. doi: 10.1021/np300699f. Epub 2013 Jan 24.

Anti-inflammatory diterpenoids from Croton tonkinensis.

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  • 1Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, Republic of China.

Abstract

Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kaurane-type diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.

PMID:
23347584
[PubMed - indexed for MEDLINE]
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