Send to

Choose Destination
See comment in PubMed Commons below
Sci Rep. 2013;3:1091. doi: 10.1038/srep01091. Epub 2013 Jan 21.

Sedimentation of macroscopic rigid knots and its relation to gel electrophoretic mobility of DNA knots.

Author information

  • 1King's College London, Materials and Molecular Modelling, The Strand, London, UK.


We address the general question of the extent to which the hydrodynamic behaviour of microscopic freely fluctuating objects can be reproduced by macrosopic rigid objects. In particular, we compare the sedimentation speeds of knotted DNA molecules undergoing gel electrophoresis to the sedimentation speeds of rigid stereolithographic models of ideal knots in both water and silicon oil. We find that the sedimentation speeds grow roughly linearly with the average crossing number of the ideal knot configurations, and that the correlation is stronger within classes of knots. This is consistent with previous observations with DNA knots in gel electrophoresis.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk