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Contact Dermatitis. 2013 May;68(5):293-9. doi: 10.1111/cod.12028. Epub 2013 Jan 24.

Impact of glove occlusion on cumulative skin irritation with or without hand cleanser-comparison in an experimental repeated irritation model.

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  • 1Department of Dermatology, University Hospital Jena, Friedrich Schiller University, Erfurter Straße 35, 07743 Jena, Germany. dimitar.antonov@med.uni-jena.de

Abstract

BACKGROUND:

Irritant contact dermatitis remains a substantial problem in the food processing industries. Irritants that are weak by themselves, such as glove occlusion and mild detergents, could interact to produce contact dermatitis.

OBJECTIVES:

To model the irritant action of an antibacterial hand cleanser and glove occlusion, with sodium lauryl sulfate (SLS) as a positive control. The effects of a pre-exposure cream and a post-exposure cream were also investigated.

METHODS:

A modified repeated short-time occlusive irritation test with 20 healthy volunteers, and application of irritants over 4 days, with pre-exposure and post-exposure creams and overnight glove occlusion, was performed. The changes in transepidermal water loss (TEWL) served as a measure of the irritant damage to the epidermal barrier.

RESULTS:

The antibacterial cleanser and the glove occlusion separately induced only minor increases in TEWL. When combined, the two showed a tandem effect, as the TEWL increase was significantly higher, and was similar to that seen with the positive control, SLS. The pre-exposure and post-exposure creams alone significantly mitigated the cumulative irritation, and this effect was strongest when the two creams were combined.

CONCLUSIONS:

Irritant contact dermatitis may develop through the tandem effects of long-term glove occlusion and the accumulation of barrier damage from hand washing, even when mild hand cleansers are employed.

© 2013 John Wiley & Sons A/S.

PMID:
23343466
[PubMed - indexed for MEDLINE]
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