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Org Lett. 2013 Feb 1;15(3):610-2. doi: 10.1021/ol3034274. Epub 2013 Jan 23.

Zamamiphidin A, a new manzamine related alkaloid from an Okinawan marine sponge Amphimedon sp.

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  • 1Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.


A manzamine related alkaloid, zamamiphidin A (1), consisting of a new heptacyclic ring system has been isolated from an Okinawan marine sponge Amphimedon sp. The structure of 1 including the relative stereochemistry was elucidated on the basis of the spectroscopic data. Compound 1 showed antibacterial activity against Staphylococcus aureus (MIC, 32 μg/mL).

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