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J Geriatr Cardiol. 2012 Dec;9(4):344-8. doi: 10.3724/SP.J.1263.2012.06251.

Association of inflammation with atrial fibrillation in hyperthyroidism.

Author information

  • 1Department of Cardiology, Suleyman Demirel University, Kurtulus Mah 122. cad. Hatice Halici apt. no: 126, 32040 Isparta, Turkey.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the relationship between inflammation and development of atrial fibrillation (AF) in patients with hyperthyroidism.

METHODS:

A total of 65 patients with newly diagnosed hyperthyroidism, 35 of whom were in sinus rhythm and 30 of whom in AF. Thirty five age- and gender-matched patients in a control group were included in the study. Factors associated with the development of AF were evaluated by multivariate regression analysis.

RESULTS:

FACTORS ASSOCIATED WITH AF IN MULTIVARIATE ANALYSIS INCLUDED HIGH SENSITIVITY C REACTIVE PROTEIN (HSCRP) [ODDS RATIO (OR): 11.19; 95% confidence interval (95% CI): 1.80-69.53; P = 0.003], free T4 (OR: 8.76; 95% CI: 2.09-36.7; P = 0.003), and left atrial diameter (OR: 1.25; 95% CI: 1.06-1.47; P = 0.008).

CONCLUSIONS:

The results of the present study suggest that HsCRP, an indicator of inflammation, free T4 and left atrial diameter are associated with the development AF in patients with hyperthyroidism.

KEYWORDS:

Atrial fibrillation; Hyperthyroidism; Inflammation

PMID:
23341838
[PubMed]
PMCID:
PMC3545250
Free PMC Article
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