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Pediatr Blood Cancer. 2013 Jul;60(7):E35-7. doi: 10.1002/pbc.24461. Epub 2013 Jan 17.

Cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children.

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  • 1Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA. mhoehn@uthsc.edu

Abstract

Dry eye disease is a well-known late complication of radiation therapy and is often difficult to treat. We evaluated the usefulness of cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children. Eleven children received cyclosporine 0.05% emulsion twice daily after failure of conventional therapy. After 6 months, dry eye manifestations improved in three children (27.3%). The remaining eight children showed no improvement with cyclosporine 0.05% ophthalmic emulsion. These results suggest that twice-daily cyclosporine 0.05% ophthalmic emulsion has limited use in children with refractory radiation-associated chronic dry eye.

Copyright © 2013 Wiley Periodicals, Inc.

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