Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Neurol Neurosurg Psychiatry. 2013 Sep;84(9):1047-53. doi: 10.1136/jnnp-2012-304498. Epub 2013 Jan 19.

Tumefactive demyelination: an approach to diagnosis and management.

Author information

  • 1Department of Neuroinflammation, National Hospital for Neurology and Neurosurgery, London, UK. thardy@med.usyd.edu.au

Abstract

Tumefactive lesions are an uncommon manifestation of demyelinating disease and can pose a diagnostic challenge in patients without a pre-existing diagnosis of multiple sclerosis. Choosing when to biopsy a tumefactive lesion to exclude alternative pathology can be difficult. Other questions include how best to treat an acute attack as well as the optimal timing of therapy to prevent relapse. This article aims to review the available literature for tumefactive demyelination and to propose an approach to diagnosis and management. We argue that disease modifying therapy should be considered for acute tumefactive demyelinating lesions only once criteria of dissemination in time and space are fulfilled and the diagnosis of multiple sclerosis is confirmed.

KEYWORDS:

Multiple Sclerosis; Neuroimmunology; Neuropathology; Neuroradiology; Tumours

PMID:
23334629
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk