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J Cell Commun Signal. 2013 Jun;7(2):119-27. doi: 10.1007/s12079-013-0190-x. Epub 2013 Jan 20.

Mechanisms of bronchopulmonary dysplasia.

Author information

  • Department of Pediatrics, University of Michigan Medical School, 1150 W. Medical Center Dr., Room 3570, MSRBII, Box 5688, Ann Arbor, MI, USA, 48109-5688, antoniap@med.umich.edu.

Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants with long term effect on lung function into adulthood. Multiple factors are involved in the development of BPD. This review will summarize the different mechanisms leading to this disease and highlight recent bench and clinical research targeted at understanding the role of the mesenchyme (both its cellular and extracellular components) in the pathogenesis of BPD.

PMID:
23334556
[PubMed]
PMCID:
PMC3660689
Free PMC Article

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