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Clin Neuropharmacol. 2013 Jan-Feb;36(1):4-7. doi: 10.1097/WNF.0b013e3182770730.

Long-term use of clobazam in Lennox-Gastaut syndrome: experience in a single tertiary epilepsy center.

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  • 1Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.



Clobazam (CLB) is a 1,5-benzodiazepine, which is known to be effective for treating refractory partial epilepsy. We have evaluated the long-term efficacy and tolerability of CLB as an add-on therapy in patients with Lennox-Gastaut syndrome (LGS).


Forty-six patients with LGS who had received CLB add-on therapy were enrolled in this study. We retrospectively reviewed their clinical characteristics, including type of seizures, use of CLB, efficacy, adverse events, and retention rate.


The mean±SD dose of CLB was 0.70±0.37 mg/kg per day (range, 0.16-1.60 mg/kg per day). After 1 month on CLB, 15 patients (32.6%) became seizure-free and 10 patients (21.7%) had 50% or greater seizure reduction. Response to CLB was not significantly associated with age, sex, or etiology (symptomatic or not). Five (10.8%) of 46 patients maintained seizure remission for more than 12 months. Tolerance developed in 48.0% of initial responders, and the 3-year retention rate by the Kaplan-Meier method was 76.6%. Seven patients (15.2%) reported adverse events, including somnolence and behavioral change, but only one discontinued CLB.


Clobazam add-on therapy was effective and very tolerable in patients with LGS.

[PubMed - indexed for MEDLINE]
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