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Urology. 2013 Mar;81(3):480-7. doi: 10.1016/j.urology.2012.11.028. Epub 2013 Jan 17.

Phosphodiesterase-5 expression and function in the lower urinary tract: a critical review.

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  • 1Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143-0738, USA. clin@urology.ucsf.edu


Both clinical and preclinical studies have mostly shown beneficial effects for Phosphodiesterase-5 (PDE-5) inhibitors in the treatment of lower urinary tract symptoms. Molecular studies have consistently shown abundant PDE-5 expression in bladder smooth muscle. Data concerning urethral PDE-5 expression have been surprising because striated muscle was not only positively identified, but also found to express more PDE-5 than the smooth muscle. In the prostate, highly variable results have been obtained. For PDE-5 expression, the data have ranged from extremely low to highly abundant. PDE-5 has been found in the glandular epithelium, vascular smooth muscle, endothelium, and fibromuscular stroma.

Copyright © 2013 Elsevier Inc. All rights reserved.

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