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Ultrasound Med Biol. 2013 Mar;39(3):507-14. doi: 10.1016/j.ultrasmedbio.2012.10.013. Epub 2013 Jan 16.

Ultrasound-mediated targeted drug delivery generated by multifocal beam patterns: an in vitro study.

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  • 1Institute for Medical Science and Technology, University of Dundee, Dundee DD2 1FD,UK.


Ultrasound-mediated targeted drug delivery has been a subject for a dedicated research activity for several decades. Nevertheless, in vitro studies in this field of research are characterized by their inconsistencies. To improve the repeatability of such experiments, a novel approach of multifocal spot generation was investigated. A multifocal pattern of 16 spots was utilized using an iterative Gerchberg-Saxton algorithm. The pattern was applied to insonate a 96-well Petri dish plate using a clinically available planar-phased array transducer with approximately 1000 elements with a central frequency of 0.55 MHz. The pattern was acoustically characterized and applied to a monolayer of human breast cancer cell line in the 96-well plate. With the help of ultrasonic contrast agents, the intracellular drug uptake was increased by an average factor of 3.5 compared with the control group.

Copyright © 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

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