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J Neuroimmunol. 2013 Mar 15;256(1-2):94-6. doi: 10.1016/j.jneuroim.2012.12.006. Epub 2013 Jan 14.

GABAB receptor antibodies in paraneoplastic cerebellar ataxia.

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  • 1Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany.


Autoantibodies to the gamma-aminobutyric acid-B (GABAB) receptor were recently described in patients with limbic encephalitis presenting with early or prominent seizures. We report on a 64-year-old man with malignant melanoma who during adjuvant therapy with interferon (IFN)-alpha developed cerebellar ataxia. Indirect immunofluorescence on brain tissue sections revealed high-titer (1:20,000) IgG1 serum autoantibodies to the cerebellar molecular and granular layer, which were confirmed to be directed against GABAB receptor in a cell-based assay. This case highlights cerebellar ataxia in the absence of seizures as a clinical manifestation of GABAB receptor autoimmunity and extends the spectrum of tumors underlying this condition to malignant melanoma. IFN-alpha therapy may have contributed to the development of autoimmunity in this patient.

Copyright © 2012 Elsevier B.V. All rights reserved.

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