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J Pediatr Surg. 2013 Jan;48(1):20-6. doi: 10.1016/j.jpedsurg.2012.10.014.

Adaptation: paradigm for the gut and an academic career.

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  • 1Division of Pediatric Surgery, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO 63110, USA. Brad.Warner@wustl.edu


Adaptation is an important compensatory response to environmental cues resulting in enhanced survival. In the gut, the abrupt loss of intestinal length is characterized by increased rates of enterocyte proliferation and apoptosis and culminates in adaptive villus and crypt growth. In the development of an academic pediatric surgical career, adaptation is also an important compensatory response to survive the ever changing research, clinical, and economic environment. The ability to adapt in both situations is critical for patients and a legacy of pediatric surgical contributions to advance our knowledge of multiple conditions and diseases.

Copyright © 2013 Elsevier Inc. All rights reserved.

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