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Clin Exp Allergy. 2013 Feb;43(2):152-63. doi: 10.1111/j.1365-2222.2012.04059.x.

Innate affairs of allergens.

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  • 1Centre for Child Health Research, University of Western Australia, Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia.


Activation of receptors of the innate immune system is a critical step in the initiation of immune responses. It has been shown that dominant allergens have properties that could allow them to interact with toll-like and C-type lectin receptors to favour Th2-biased responses and many bind lipids and glycans that could associate with ligands to mimic pathogen-associated microbial patterns. In accord with the proposed allergen-specific innate interactions it has been shown that the immune responses to different allergens and antigens from the same source are not necessarily coordinately regulated.

© 2012 Blackwell Publishing Ltd.

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