Nature. 1990 May 17;345(6272):229-33.

Molecular genetic basis of the histo-blood group ABO system.

Yamamoto F, Clausen H, White T, Marken J, Hakomori S.

Source

Biomembrane Institute, Seattle, Washington.

Abstract

The histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities converting the H antigen into A or B antigens, whereas O(H) individuals lack such activity. Here we present a molecular basis for the ABO genotypes. The A and B genes differ in a few single-base substitutions, changing four amino-acid residues that may cause differences in A and B transferase specificity. A critical single-base deletion was found in the O gene, which results in an entirely different, inactive protein incapable of modifying the H antigen.

PMID:: 2333095; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. [Biochim Biophys Acta. 1999]
Review Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer.
Hakomori S. Biochim Biophys Acta. 1999 Dec 6; 1473(1):247-66.
ABH and related histo-blood group antigens in normal & malignant human endometrium in relation to genetic and hormonal factors. [APMIS Suppl. 1997]
ABH and related histo-blood group antigens in normal & malignant human endometrium in relation to genetic and hormonal factors.
Skovlund VR. APMIS Suppl. 1997; 69:1-33.
Determination of ABO glycosyltransferase genotypes by use of polymerase chain reaction and restriction enzymes. [Transfusion. 1995]
Determination of ABO glycosyltransferase genotypes by use of polymerase chain reaction and restriction enzymes.
Stroncek DF, Konz R, Clay ME, Houchins JP, McCullough J. Transfusion. 1995 Mar; 35(3):231-40.
Evaluation of histo-blood group ABO genotyping in a Danish population: frequency of a novel O allele defined as O2. [Vox Sang. 1994]
Evaluation of histo-blood group ABO genotyping in a Danish population: frequency of a novel O allele defined as O2.
Grunnet N, Steffensen R, Bennett EP, Clausen H. Vox Sang. 1994; 67(2):210-5.
Review Molecular genetics of the ABO histo-blood group system. [Vox Sang. 1995]
Review Molecular genetics of the ABO histo-blood group system.
Yamamoto F. Vox Sang. 1995; 69(1):1-7.

See reviews... See all...

Cited by 49 PubMed Central articles

Genetic and Mechanistic Evaluation for the Mixed-Field Agglutination in B(3) Blood Type with IVS3+5G>A ABO Gene Mutation. [PLoS One. 2012]
Genetic and Mechanistic Evaluation for the Mixed-Field Agglutination in B(3) Blood Type with IVS3+5G>A ABO Gene Mutation.
Chen DP, Tseng CP, Wang WT, Sun CF. PLoS One. 2012; 7(5):e37272. Epub 2012 May 18.
Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1. [PLoS One. 2011]
Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1.
Perrin-Tricaud C, Rutschmann C, Hennet T. PLoS One. 2011; 6(12):e29390. Epub 2011 Dec 21.
The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes. [Clin Dev Immunol. 2012]
The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes.
Ahlen MT, Husebekk A, Killie MK, Kjeldsen-Kragh J, Olsson ML, Skogen B. Clin Dev Immunol. 2012; 2012:156867. Epub 2011 Nov 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Molecular genetic basis of the histo-blood group ABO system.
Molecular genetic basis of the histo-blood group ABO system.
Nature. 1990 May 17 ;345(6272):229-33.

PubMed
Preservation of sexual function in men during radical pelvic surgery.
Preservation of sexual function in men during radical pelvic surgery.
Md Med J. 1990 Apr ;39(4):389-93.

PubMed
Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Y...
Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Yoshida sarcoma cells by inhibitor proteins from cobra venom.
Cancer Biochem Biophys. 1979 ;3(3):123-7.

PubMed
Methods of smoking cessation--finally, some answers.
Methods of smoking cessation--finally, some answers.
JAMA. 1990 May 23-30 ;263(20):2795-6.

PubMed
Localization of the diphtheria toxin receptor-binding domain to the carboxyl-ter...
Localization of the diphtheria toxin receptor-binding domain to the carboxyl-terminal Mr approximately 6000 region of the toxin.
J Biol Chem. 1990 May 5 ;265(13):7331-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: