Cancer Biochem Biophys. 1979;3(3):123-7.

Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Yoshida sarcoma cells by inhibitor proteins from cobra venom.

Abstract

Inactivation of (Na+ + K+)-ATPase of Yoshida sarcoma cells and beef brain microsomes by phospholipase A2 and a cytotoxin P6 from snake venom has been examined in relation to their activity to degrade phospholipids. Cytotoxin P6 which was most basic and devoid of phospholipase activity was most effective in inhibiting the (Na+ + K+)-ATPase of Yoshida sarcoma cells. Phospholipase A2 from Naja naja which was most active in degrading phospholipids was least effective in inhibiting (Na+ + K+)-ATPase in Yoshida sarcoma cells or in beef brain microsomes. Addition of trace amounts of cytotoxin P6 to the phospholipase considerably enhanced the inactivation of (Na+ + K+)-ATPase. The evidence suggests that the charge of the inhibitor protein and its specific structure play an important role in the inactivation of (Na+ + K+)-ATPase.

PMID:: 233302; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Molecular Biology Databases

LECITHIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Inactivation of membrane-bound (Na+ +K+)-ATPase of Yoshida sarcoma cells and cobra venom cytotoxin complex with the glycolipid components of the enzyme system. [Cancer Biochem Biophys. 1979]
Inactivation of membrane-bound (Na+ +K+)-ATPase of Yoshida sarcoma cells and cobra venom cytotoxin complex with the glycolipid components of the enzyme system.
Mone MD, Zaheer A, Fialho MJ, Braganca BM. Cancer Biochem Biophys. 1979; 4(1):37-41.
[Effect of phospholipases A2 from bee and cobra venom on the phospholipid composition and Na+-,K+-ATPase activity of synaptosomes]. [Ukr Biokhim Zh. 1985]
[Effect of phospholipases A2 from bee and cobra venom on the phospholipid composition and Na+-,K+-ATPase activity of synaptosomes].
Vavilova GL, Kirsenko OV, Kocherga VI. Ukr Biokhim Zh. 1985 Nov-Dec; 57(6):28-34.
Inactivation of (Na-++K-+)-stimulated ATPase by a cytotoxic protein from cobra venom in relation to its lytic effects on cells. [Biochim Biophys Acta. 1975]
Inactivation of (Na-++K-+)-stimulated ATPase by a cytotoxic protein from cobra venom in relation to its lytic effects on cells.
Zaheer A, Noronha SH, Hospattankar AV, Braganca BM. Biochim Biophys Acta. 1975 Jun 25; 394(2):293-303.
On the inhibition of [Na+,K+]-ATPases by the components of Naja mossambica mossambica venom: evidence for two distinct rat brain [Na+,K+]-ATPase activities. [Biochemistry. 1989]
On the inhibition of [Na+,K+]-ATPases by the components of Naja mossambica mossambica venom: evidence for two distinct rat brain [Na+,K+]-ATPase activities.
Bougis PE, Khélif A, Rochat H. Biochemistry. 1989 Apr 4; 28(7):3037-43.
[Effect of phospholipase A2 from Naja naja oxiana venom on activity of Na+,K+-ATPase isoenzymes in rat brain]. [Biokhimiia. 1996]
[Effect of phospholipase A2 from Naja naja oxiana venom on activity of Na+,K+-ATPase isoenzymes in rat brain].
Kaplia AA, Kravtsova VV, Kravtsov AV. Biokhimiia. 1996 Jun; 61(6):998-1005.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Y...
Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Yoshida sarcoma cells by inhibitor proteins from cobra venom.
Cancer Biochem Biophys. 1979 ;3(3):123-7.

PubMed
Methods of smoking cessation--finally, some answers.
Methods of smoking cessation--finally, some answers.
JAMA. 1990 May 23-30 ;263(20):2795-6.

PubMed
Localization of the diphtheria toxin receptor-binding domain to the carboxyl-ter...
Localization of the diphtheria toxin receptor-binding domain to the carboxyl-terminal Mr approximately 6000 region of the toxin.
J Biol Chem. 1990 May 5 ;265(13):7331-7.

PubMed
Changes in lymphocyte beta-adrenergic receptors in depression and mania.
Changes in lymphocyte beta-adrenergic receptors in depression and mania.
Psychiatry Res. 1979 Oct ;1(2):191-7.

PubMed
Mass spectrometric identification of 2-hydroxydodecanedioic acid and its homolog...
Mass spectrometric identification of 2-hydroxydodecanedioic acid and its homologues in urine from patients with hopantenate therapy during clinical episode.
Biomed Environ Mass Spectrom. 1990 Mar ;19(3):171-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Influence of charge on the inactivation of membrane bound (Na+ + K+)-ATPase of Yoshida sarcoma cells by inhibitor proteins from cobra venom.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information