Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Dermatol Case Rep. 2012 Dec 31;6(4):108-12. doi: 10.3315/jdcr.2012.1117.

Granulomatous slack skin. Histopathology diagnosis preceding clinical manifestations by 12 years.

Author information

  • 1Sector of Dermatology and Post Graduation Course - HUCFF-UFRJ and School of Medicine, Federal University of Rio de Janeiro, Brazil.

Abstract

BACKGROUND:

Granulomatous slack skin is a very rare subtype of T-cell cutaneous lymphoma, characterized by the slow development of cutaneous sagging, especially on flexural areas. Its behavior is indolent and the treatment, in the majority of cases, disappointing.

MAIN OBSERVATION:

We report a 54-year-old black patient with granulomatous slack skin, who at the beginning of the investigation showed intense xeroderma and generalized lymph node enlargement. The diagnosis was established based on histopathologic findings long before the disease's characteristic clinical presentation appeared.

CONCLUSIONS:

During the twelve years of follow-up, the clinical manifestation evolved to marked skin looseness, most predominant in flexural regions, illustrating the clinical hallmark of granulomatous slack skin, long after first histological abnormalities were observed.

KEYWORDS:

cutaneous T-cell lymphoma; diagnosis; granulomatous cutis laxa; granulomatous slack skin; lymphoma; mycosis fungoides; orcein staining; treatment

PMID:
23329989
[PubMed]
PMCID:
PMC3543856
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk